Proteins – Communicable Diseases Research

Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway

Article

Published on 2023-01-302022-11-15
Journal: Journal of ethnopharmacology
[Category] 유전자 메커니즘, 진단,

[키워드] Activation acute lung injury ALI model alleviate analysis Analysis attenuate Baidu caused Cell cellular China component Component analysis components Compound COVID-19 COVID-19 patients demonstrated experiment experimental validation Formula in vivo increases in indicated Inflammation ingredient inhibited inhibiting Kyoto lung Lung injury material mechanism of action Mild molecular mechanism network network pharmacology NF-κB pathway NF-κB signaling NF-κB signaling pathway Obstructive Ontology p-NF-κB p65 pathway pharmacological predicted proinflammatory Proteins reduced syndrome target treat Treatment Xuanfei baidu formula.
[DOI] 10.1016/j.jep.2022.115833 PMC 바로가기

An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extracts

Article

Published on 2023-01-152022-11-15
Journal: Talanta
[Category] SARS, 유전자 메커니즘, 치료제,

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants
[DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article

Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)

Article

Published on 2022-11-302022-09-11
Journal: Human vaccines & immunotherapeutics
[Category] SARS, 유전자 메커니즘,

[키워드] Anti-viral B cell Blood candidate vaccine CD4 CD8 Cell clinical condition Cord blood COVID-19 COVID-19 research cytotoxic activity DRAGA mice Efficacy epithelial Express expressing functional granzyme B Hematopoietic stem cell Human human ACE2 receptor human antibodies Human immune system human lung-resident CD8 T cells humanized humanized mice IgG antibody immune immunopathological in vivo infused intra-alveolar lung lung immunopathology lung immunopathology. Lungs lymphocyte mechanism mice microthrombi mounted perforin promote Proteins replicating virus response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secreted surrogate switching System T cell T cells Therapeutics unique upper respiratory airway Viral proteins
[DOI] 10.1080/21645515.2022.2048622 PMC 바로가기 [Article Type] Article

Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development

Article

Published on 2022-11-142022-11-15
Journal: Angewandte Chemie (International ed. in English)
[Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제,

Characterization and immunogenicity of SARS-CoV-2 spike proteins with varied glycosylation

Article

Published on 2022-11-082022-11-15
Journal: Vaccine
[Category] SARS, 진단,

[키워드] 293 cells 293F cell acute respiratory syndrome addition binding caused Cell changed characterization convalescent sera coronavirus Coronavirus disease-19 COVID-19 Critical discrepancy effective Efficacy elicited exhibited expression globe glycosylated glycosylation glycosylation pattern homogeneity host cells IgG immunization immunogenicity insect cell mammalian cells mice Neutralizing antibody response neutralizing antibody titre pandemic Protein Proteins provide reactivity Receptor binding regimen robust S protein S-2P SARS-CoV-2 SARS-CoV-2 spike protein spike Spike. the S protein thermal stability Vaccine Vaccine design Variation virus virus entry while
[DOI] 10.1016/j.vaccine.2022.09.057 PMC 바로가기

The human host response to monkeypox infection: a proteomic case series study

Article

Published on 2022-11-082022-11-16
Journal: EMBO Molecular Medicine
[Category] 유전자 메커니즘,

Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review

Article

Published on 2022-11-012022-11-16
Journal: Annals of Clinical and Translational Neurology
[Category] 변종,

Repurposing of the herbal formulations: molecular docking and molecular dynamics simulation studies to validate the efficacy of phytocompounds against SARS-CoV-2 proteins

Article

Published on 2022-11-012022-11-16
Journal: Journal of biomolecular structure & dynamics
[Category] SARS, 신약개발,

Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targets

Article

Published on 2022-11-012022-11-15
Journal: Journal of biomolecular structure & dynamics
[Category] SARS, 치료제,